A Continuous Newman-Kwart Rearrangement Reaction Using Supercritical Glyme
Special Symposium - EPIC-1: European Process Intensification Conference - 1
EPIC-1: Poster Session (EPIC - Poster) - P1
Keywords: pharmaceutical synthesis, continuous reaction, Newman Kwart rearrangement
Joel R. Calvin, Martin D. Johnson,
Eli Lilly and Company, Chemical Process Research and Development Division, Indianapolis, Indiana 46285, U.S.A.
Ulf Tilstam
CMC Solutions Laboratories, Rue du Laid Burniat 5, B-1348 Louvan-La-Neuve, Belgium.
A simple, continuous Newman-Kwart1 rearrangement reaction using a custom thermal tube reactor system has been demonstrated. On 200 gram scale the process was carried out in supercritical glyme under 280-300°C at > 70 bar to afford a 92% yield in 4 hours.
Presented Wednesday 19, 13:30 to 14:40, in session EPIC-1 Poster Session (EPIC - Poster) - P1.
