Kilogram Scale Production of trans-1,4-cyclohexane dicarboxylic acid via Continuous Thermal epimerization

Special Symposium - EPIC-1: European Process Intensification Conference - 1

EPIC-1: Poster Session (EPIC - Poster) - P1

Mr Timothy Braden
Eli Lilly and Company
Chemical Product Research and Development
Indianapolis, Indiana 46285
United States of America

Keywords: pharmaceutical synthesis, continuous reaction, thermal epimerization

A. Timothy M. Braden, B. Martin D. Johnson, C. Ru Lin Gu, D. Sreenivasa Mundla, E. Tony Y. Zhang

A simple, scaleable, continuous process for the production of trans-1,4-cyclohexanedicarboxylic acid using a custom thermal tube reactor system has been developed. This continuous process avoids the use of a solid-melt process using costly specialized processing equipment.

Presented Wednesday 19, 13:30 to 14:40, in session EPIC-1 Poster Session (EPIC - Poster) - P1.