Toxicity of nanoparticles on mammalian cells
Integration of life sciences & engineering
Integration of Life Sciences & Engineering - Poster (T5-P)
Keywords: toxicity, nano particles, mammalian cells
Abstract:
Nanoscience and nanotechnologies have been widely recognized to have huge potential to affect drug development, water decontamination, development of information and communication technologies, and the production of stronger and lighter materials. However, concerns about the possible side effects of the extensive application of nanotechnology regarding various aspects, including the ecosystem, human health, food and agricultural industries, have been raised recently. In this study, the toxicity of buckyball on two mammalian cell lines, i.e., the Chinese hamster ovary (CHO) cell and MDCK (NBL-2) cell, has been investigated. Although buckyball particles have a very low solubility in DI water (< 1 pg/L), its solubility could be significantly increased from tens to hundreds mg/L through the formation of particle aggregates. Results presented here show that, once the concentration of the buckyball aggregates reaches a certain level, both types of cells start to die. The critical dosage, which is defined as the lowest buckyball concentration present in a given cell culture that results in 50% cell death within 24 hours, has been determined. The interaction between the buckyball particles and a given type of cells has been studied. Further, the mechanism which causes the cell’s death has been analyzed. These results will help to better understand the side effects of the nanotechnology in living systems.
Presented Wednesday 19, 13:30 to 15:00, in session Integration of Life Sciences & Engineering - Poster (T5-P).
