Enzymatic Kinetic Resolution in water / scCO2 biphasic systems
Special Symposium - EPIC-1: European Process Intensification Conference - 1
EPIC-1: Poster Session (EPIC - Poster) - P1
Keywords: kinetic resolution, enzyme, biphasic system, supercritical carbon dioxide,
Enantiopure chemicals are important intermediates and products for pharmaceuticals, food industry, agrochemicals, and cosmetics. Kinetic resolution of racemates is still the most widely used method in industrial applications because of its general applicability. It is the main field of application for enzymatic catalysis. The main disadvantage of limited conversion and sometimes down stream processing can be overcome by dynamic kinetic resolution. The combination of enzymatic kinetic resolution and transition metal catalysed racemisation, as introduced recently by Bäckvall and co-workers, is a powerful tool in the synthesis of enantiopure chemicals and allows racemisation and kinetic resolution under mild conditions. Remaining problems of this approach are the removal and/or recycling of the precious metal catalyst and the need for reaction conditions to be compatible.
We aim to overcome these issues by compartimentisation of the catalyst by immobilisation and the use of supercritical carbon dioxide as transporting vector between the catalysts and for extraction.
Within this work a way to use enzymes in a continuous process with water as reaction medium for kinetic resolution in combination with scCO2 is presented. Comparison of batch and continuous processing in scCO2 will be presented as well as the characterisation of the reaction system in respect to kinetics and the influence of phase behaviour.
Presented Wednesday 19, 13:30 to 14:40, in session EPIC-1 Poster Session (EPIC - Poster) - P1.
