SUPERCRITICAL FLUID EXTRACTION OF BIOACTIVE COMPOUNDS FROM SUNFLOWER LEAVES: COMPARISON OF ANALYTICAL AND PILOT-SCALE EXTRACTION
Advancing the chemical engineering fundamentals
Distillation, Absorption & Extraction (T2-10P)
Keywords: sunflower, supercritical fluid extraction, scale-up
Lourdes Casas Cardoso, e-mail: lourdes.casas@uca.es
Casimiro Mantell Serrano, e-mail: casimiro.mantell@uca.es
Miguel Rodríguez Rodríguez, e-mail: miguel.rodri@uca.es
Enrique Martínez de la Ossa, e-mail: enrique.martinezdelaossa@uca.es
Ascensión Torres Martínez, e-mail: ascension.torres@uca.es
Francisco Antonio Macias, e-mail: fa.macias@uca.es
Analysis and design of processes with supercritical fluids Group –Dep. Chemical Engineering & Foods Technology & Environmental Technology
University of Cadiz, Box 40, CP 11510, Puerto Real, SPAIN.
Phone: 34 956 016458 , Fax: 34-956016411
Supercritical fluid extraction (SFE) from natural products has been widely studied as an alternative to the use of traditional techniques in the production of bioactive compounds. It has been demonstrated that this process is particularly useful when treating thermolabile compounds and solvent pollution has to be avoided.
SFE can be applied to systems of different scales, for instance, from analytical scale (less than a gram to a few grams of sample), to pilot plant scale (several hundred grams or kilograms of sample) and up to large industrial scale (tons of raw material, such as SFE of coffee beans).
In most of these studies carbon dioxide was used as the solvent because of its relatively low critical temperature (31.1 ºC), non-toxicity, non-flammability, good solvent power, ease of removal from the product and low cost. However, quantitative extraction of polar analytes requires the addition of an organic modifier, water is the most common choice in natural products.
The work described here involved the extraction of bioactive compounds from the sunflower (Helianthus annuus L) with CO2 and CO2+H2O.
The extractions were carried out in an analytical Isco extractor (Nebraska, USA, model SFX 220) with one extractor with a maximum capacity of 10 ml and in a pilot plant from Thar Technology (Pittsburgh, PA, USA) model SF2000 provided with a extraction vessel with a capacity of 2 L. The extraction pressure and temperature were optimized in previous works and has been 380 bar of pressure and 50 ºC of temperature. In order to achieve complete extraction of the substances in question, a relatively long extraction time was used (5 h). The experimental data obtained of both were compared and the implications of this analysis on the development of scale-up procedures were also discussed.
The relations and parameters studies were: H/d (H: height of extractor and d: diameter of extractor); solvent velocity; Qmd/M (Qm: mass flow and M: amount of sample); and Reynolds number.
A comparison on the basis of geometric similarity and dimensionless considerations was developed for an analysis of the supercritical extraction process of bioactive compounds from leaves of Helianthus annuus L.
See the full pdf manuscript of the abstract.
Presented Tuesday 18, 13:30 to 15:00, in session Distillation, Absorption & Extraction (T2-10P).
