DRUG DELIVERY SYSTEMS – PRODUCTION OF PARTICLES USED TO INHALATION PROCESS AND CONTROLLED RELEASE OF DRUGS
Multi-scale and/or multi-disciplinary approach to process-product innovation
Controlled Release of the Active Ingredient: Mechanisms, Devices & Analysis (T3-2P)
Keywords: EHDA, Spray Drying, Controlled Release, Paracetamol, Polycaprolactone
The aim of the work was to produce particles used for controlled release of drug which could be applied to medical purposes e.g. inhalation. The Electro Hydro Dynamic Atomization (EHDA) and Spray Drying Process (SDP) was used as a tool in particle production. As a precursors for this process solution of biodegradable and biocompatible polymers as a poly caprolactam, poly ethyl glycol and poly lactic acid and medicines (e.g. paracetamol) were used. The particles produced this way could slowly release medicines inside human body.
Liquid was supplied to the nozzle connected with: high voltage source (EHDA) or the high air pressure source (SDP). In EHDA to stabilize the process a ring shape electrode was placed under the nozzle and connected to the lower potential. To make particles manageable a discharge electrode was placed opposite the spraying nozzle. In both apparatus particle were drown by the flowing air but collected in different ways: on the glossy surface (EHDA) or in a cyclone (SDP).
The particles obtained in both apparatus were very small (less than 20 micrometers) – called nanoparticles. Techniques are delicate and soft, so the drugs can be atomized or sprayed in undisturbed conditions.
This techniques could enter here as a flexible method of producing particles of a fragile biochemical compounds or targeted drugs.
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See the full pdf manuscript of the abstract.
Presented Tuesday 18, 13:30 to 15:00, in session Controlled Release of the Active Ingredient: Mechanisms, Devices & Analysis (T3-2P).
