Correlation of Fluid Atomization and Particle Formation in the SAS Process by Optical Laser Analysis
Advancing the chemical engineering fundamentals
Crystallization (T2-9P)
Keywords: SAS, supercritical antisolvent, elastical light scattering, linear Raman scattering
A variety of supercritical fluid atomization processes are used for the production of fine powders particularly in the pharmaceutical industry. Important properties such as particle size, morphology, and particle size distribution can be influenced by varying parameters such as concentration, pressure, and temperature. However, the requirement of high pressure equipment and the expeditious process complicate the analysis of the particle formation mechanism. The supercritical antisolvent (SAS) method was examined using optical laser analysis detecting propagation, concentration, and the corresponding state of phase within the injected solution atomized inside the precipitation chamber. A pulsed, piezoelectric actuated injector was used to atomize an ethanol solution of acetaminophen into supercritical carbon dioxide. Elastical light scattering and linear Raman scattering were applied as optical measuring techniques to analyze the process of mixture formation. Evaluating these results with regard to the properties of particles produced allows an insight on the particle formation process.
Presented Wednesday 19, 13:30 to 15:00, in session Crystallization (T2-9P).
