Topical 2: Discover, Development and Delivery of Medicines | |||
| Session 661 - Control of polymorphism of APIs or broader value-added materials | |||
| Different polymorphs of the same chemical entity display distinct physical properties, such as melting point, solubility, dissolution rate, hygroscopicity, stability, etc. The ability to successfully produce and reproduce specific polymorphic modifications is intricately correlated with the efficiency and speed of materials development, the robustness of manufacturing process, and – ultimately – the stability and quality of the targeted value-added materials. Papers are invited on all aspects of the control of polymorphism and pseudopolymorphism, applicable to pharmaceutical development or manufacture of other value-added materials. | |||
| Chair: | Peter Karpinski | ||
| CoChair: | Sridhar Desikan | ||
| CoSponsor(s): | Crystallization and Evaporation Pharmaceuticals (See also Topical 2) | ||
| Introductory Remarks | |||
| 661a | Effective Evaluation of Solid-Phase Free Energies Nancy Cribbin, Andrew J. Schultz, Kenneth M. Benjamin, David A. Kofke | ||
| 661b | Impact of Phase Split Ratio on Agglomeration Behavior in an Api Crystallization Shekhar K. Viswanath, Ahmad Sheikh, John Tolle, Agnes Pal, James Marek | ||
| 661c | Investigation on Polymorphic Transformations of Api Using Raman Spectroscopy Lili Feng, Zhaoxia Liu, Peter Karpinski | ||
| 661d | The Kinetics of L-Glutamic Acid Precipitation: Characterization and Modeling Marco Mazzotti, Lars Vicum, Christian Lindenberg, Jochen Schöll, Jörg Brozio | ||
| 661e | Polymorphism in the Crystallization of Glycine Xia Yang, Chi Bun Ching, Xiu Juan Wang, Jie Lu | ||
| 661f | Direct Growth of Gamma Glycine from Neutral Aqueous Solutions by Slow, Evaporation-Driven Evaporation Paul J. A. Kenis, Guangwen He, Venkateswarlu Bhamidi, Scott R. Wilson, Reginald B. H. Tan, Charles F. Zukoski | ||
| Concluding Remarks | |||
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