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T. Larsson, S. Skogestad, K. Hestetun, ``Self-optimizing control of a large-scale plant: The Tennessee Eastman process'', Symposium Chemical Process Control 6, Tucson, Arizona, 7-12 Jan. 2001, Preprints pp. 481-486.

Abstract.
The paper addresses the selection of controlled variables,that is, "what should we control". The concept of self-optimizing control provides a systematic tool for this, and in the paper we show how it may be applied to the Tennessee Eastman process which has a very large number of candidate variables. In the paper we present a systematic procedure for reducing the number of alternatives. One step is to eliminate variables which with constant setpoints result in large losses or infeasibility when there are disturbances (with the remaining degrees of freedom reoptimized).