Nanotechnology has emerged as an exciting area of science with a wide range of applications in biology, medicine, and pharmaceutics. Polymer-based nanogels are of especial interest in drug delivery and diagnostic applications because of tunable chemical and physical properties. In this work, we report the synthesis and characterization of nanogels based on N-isopropyl acrylamide (NIPAAM) and 2-hydroethylmethacrylate-lactate-dextran (macromer) having both of thermoresponsive and degradable properties that may have potential anti-cancer characteristics. The nanogels with varying mass ratios between NIPAAM and macromer were synthesized in aqueous medium using ultra-violet photo-crosslinking and characterized by dynamic light scattering method. Anti-cancer property of the nanogels with and without doxorubicin are being studied with U87 tumor cells. The developed nanogels have great potential for targeted cancer therapy.