Shake flasks and bench-top bioreactors are the current standard scale-down models in cell culture process development. However, these platforms have throughput concerns that limit the number of parameters that can be explored simultaneously. BioProcessors' SimCell MicroBioreactor Array (MBA) technology is a high throughput system that enables over 1000 independent cell culture experiments to be conducted simultaneously. The system is capable of controlling typical process parameters, such as pH, temperature, dissolved oxygen and carbon dioxide, and can be operated in standard production modes such as batch and fed batch. It is also possible to combine these factors with various media optimization and feeding strategies. This capacity allows multi-factorial experimental designs to be performed rapidly with a high level of control and data quality at a cost that cannot be achieved with conventional techniques. Examples using the SimCell platform which demonstrate its potential for high throughput cell culture development will be given.