Combining ozone (O₃) and hydrogen peroxide (H₂O₂), the process known as peroxone, produces intermediate species with even greater oxidizing power than either parent oxidant, including trioxide (H₂O₃ or HO₃^•), ozonide (O₃^•), the hydroxyl radical (OH^Ÿ) and the peroxyl radical (HO₂^Ÿ).  The production mechanism of these species has been determined experimentally and through quantum calculations to initiate through the formation of a ring species ([HO₂][HO₃]).  The only other well known example is the combination of H₂O₂ and permanganate (MnO₄^-) in phosphate buffer, resulting in an oscillating reaction in which MnO₄^- is regenerated, but intermediate species that are involved in this phenomenon have not been identified.  This paper presents the approach and preliminary findings of scoping experiments designed to understand the interactions of O₃, MnO₄^-, H₂O₂, peroxynitrite (ONOO^-), ferrate (FeO₄^2-), and peroxyacetate (CH₃CO(O)O^-) in the alkaline oxidation of chromium (from Cr(III) to Cr(VI)).  This method is being evaluated as an optimization of the baseline method for the Hanford Waste Treat Plant (WTP).