Topical 2: Discover, Development and Delivery of Medicines | |||
| Session 485 - Advances in Protein Structure, Function, Analysis and Stability - I | |||
| This session seeks submissions in the areas of experimental, theoretical, and computational approaches to rational prediction, design, and/or optimization of protein structure, stability, and function in laboratory and processing settings relevant to biopharmaceutical products in general. Studies may include structural analysis and engineering of proteins, creation or optimization of function, thermodynamics and dynamics of protein conformational stability, issues in folding or misfolding, degradation via physical and chemical routes, or related concerns in intracellular expression and refolding, purification, and final product formulation. Preference will be given to papers dealing with strategies that are relevant to commercial and biological systems and also provide insights into the molecular pathways or mechanisms controlling behavior. | |||
| Chair: | Christopher J. Roberts | ||
| CoChair: | Jeffrey J. Gray | ||
| 485a | A Novel Cytokine Recognition Mode in the Structure of Interleukin-2 Complexed with Its Alpha Receptor Mathias Rickert, K. Chris Garcia | ||
| 485b | An Interior Water Is Essential for Maintaining the Structure of Fkbp12 Sheldon Park, Szilvia Szep, Eric T. Boder, Gregory Van Duyne, Jeffery G. Saven | ||
| 485c | Binding Site Allostery in the E. Coli Groel Chaperonin Subunit Yelena R. Sliozberg, Cameron F. Abrams | ||
| 485d | Local Motions in Allosteric Proteins Michael Daily, Jeffrey J. Gray | ||
| 485e | A Novel Approach for Alpha-Helical Topology Prediction in Globular Proteins Scott R. McAllister, Christodoulos A. Floudas | ||
| 485f | An Antibody Loop Replacement Design Feasibility Study and a Loop-Swapped Dimer Structure Louis A. Clark | ||
| 485g | A Branch-and-Reduce Algorithm for the Contact Overlap Problem Wei Xie, Nick Sahinidis | ||
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