Topical 2: Discover, Development and Delivery of Medicines | |||
| Session 529 - Advances in Protein Structure, Function, Analysis and Stability - II | |||
| This session seeks submissions in the areas of experimental, theoretical, and computational approaches to rational prediction, design, and/or optimization of protein structure, stability, and function in laboratory and processing settings relevant to biopharmaceutical products in general. Studies may include structural analysis and engineering of proteins, creation or optimization of function, thermodynamics and dynamics of protein conformational stability, issues in folding or misfolding, degradation via physical and chemical routes, or related concerns in intracellular expression and refolding, purification, and final product formulation. Preference will be given to papers dealing with strategies that are relevant to commercial and biological systems and also provide insights into the molecular pathways or mechanisms controlling behavior. | |||
| Chair: | Christopher J. Roberts | ||
| CoChair: | Jeffrey J. Gray | ||
| 529a | Structure and Aggregation in a Simple Helix-Forming Polymer James Magee, Leo Lue, Robin Curtis | ||
| 529b | Smart Polymer Enhanced Protein Refolding: Molecular Dynamic Simulation and Experimental Validation Diannan Lu, Zheng Liu, Jianzhong Wu | ||
| 529c | Computer Simulation of Protein Aggregation Kinetics Using an Intermediate Resolution Model Erin M. Phelps, Carol K. Hall | ||
| 529d | Structure, Stability and Formation of the Nucleus in Polyglutamine Aggregation Allam S. Reddy, Manan Chopra, Nitin Rathore, Juan J. De Pablo | ||
| 529e | Salt Effects on the Aggregation of Amyloid Fibril Forming Proteins James M. Broering, Victor Yeh, Andreas S. Bommarius | ||
| 529f | Molecular Insights into Interactions between Misfolded Proteins and Application to Prion Transmission Barriers Peter M. Tessier, Susan Lindquist | ||
| 529g | Protein Aggregation at Interfaces – Lipid Induced Amyloid-Beta Fibril Formation Eva Y. Chi, Canay Ege, Shelli L. Frey, Ka Yee C. Lee | ||
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