Thermodynamics and Transport Properties | |||
| Session 24 - Fundamentals of Protein Degradation and Stabilization | |||
| Protein degradation occurs throughout the life cycle of biotechnology products, and can involve a variety of physical and chemical routes. This session seeks contributions that focus at a fundamental level on the mechanism(s), kinetics, and/or quantitative modeling of one or more degradation pathways for proteins in vitro or in vivo. These may include, but are not limited to: deamidation, oxidation, proteolysis, and non-native aggregation. Priority will be given to those contributions that provide insights or applications of general use, and those that apply modern computational or theoretical tools. | |||
| Chair: | Christopher J. Roberts | ||
| CoChair: | Bernhardt L. Trout | ||
| 24a | Self-Assembly, Phase Separation, and Unfolding of Coarse-Grained Proteins in Solution Jason K. Cheung, Vincent K. Shen, Jeffrey R. Errington, Thomas M. Truskett | ||
| 24b | Computer Simulation of Fibril Forming Peptides with an Intermediate Resolution Protein Model Victoria Wagoner, Carol K. Hall | ||
| 24c | Computing Free Energies of Peptide-Mediated Protein-Protein Interactions in Modeling Immune System Response Jindal K. Shah, Dilip Asthagiri, Michael E. Paulaitis | ||
| 24d | Impact of Ion Hydration and Preferential Interactions on Salt-Induced Protein Deactivation Kinetics James M. Broering, Andreas S. Bommarius | ||
| 24e | Thermodynamics, Structure, and Oligomerization States of Key Intermediates in Non-Native Chymotrypsinogen Aggregate Initiation and Growth Jennifer Andrews, Christopher J. Roberts | ||
| 24f | Structural Studies of the Self-Assembly and Stability of Viral Capsids Hung D. Nguyen, Charles L. Brooks III | ||
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