In this research, modeling and open-loop control of blood glucose for a type-1 patient using a model extended from the works of Hovorka and his coworkers (Hovorka et al., 2002; Hovorka et al., 2004; Wilinska et al., 2005) are studied. Clinical data from a continuous glucose monitoring system is used to develop the model for such use. Open-loop control strategies for patients that use subcutaneous infusions via an insulin pump or subcutaneous basal plus bolus injections before each meal are presented