LIST OF PUBLICATIONS

Catharina de Lange Davies

Thesises

1. Davies, C. de L. Transformation of hamster embryo cells using carcinogens. The role of proteolytic enzymes. Master of Science, Department of Physics, The Norwegian Institute of Technology, University of Trondheim, 1981.

2. Davies, C. de L. Microenvironment- and therapy-induced changes in the expression of tumour-associated antigens. Ph.D. Thesis. University of Oslo, 1990.

Reports

Davies, C., and Sanner, T. Air pollution and Lung Cancer. Department of Environmental and Occupational Cancer. The Norwegian Radium Hospital, Oslo, 1983.

Papers

1. Davies, C., Rivedal, E., and Sanner, T. Fibrinolytic activity and morphological transformation of hamster embryo cells. Carcinogenesis, 3, 621-624, 1982.

2. Kvaløy, S., Lindmo, T., Davies, C., Wisløff, F., and Godal, T. Sezary cells with an unusual phenotype, their modulation with 12-0-tetradecanoyl phorbol-13-acetate (TPA) in vitro, and their relationship to T-cell development. J. Clin. Immunol., 3, 212-221, 1983.

3. Lindmo, T., Davies, C., Rofstad, E.K., Fodstad, Ø., and Sundan, A. Antigen expression in human melanoma cells in relation to growth conditions and cell-cycle distribution. Int. J. Cancer, 33, 167-171, 1984.

4. Lindmo, T., Davies, C., Fodstad, Ø., and Morgan, A.C. Stable quantitative differences of antigen expression in human melanoma cells isolated by flow cytometric cell sorting. Int. J. Cancer, 34, 507-512, 1984.

5. Davies, C. de L., Rofstad, E.K., and Lindmo, T. Hyperthermia-induced changes in antigen expression on human FME melanoma cells. Cancer Res., 45, 4109-4114, 1985.

6. Blomhoff, H.K., Davies, C., Ruud, E., Funderud, S., and Godal, T. Distinct effects of g-interferon on human B-lymphocyte precursor cell-lines. Scand. J. Immunol., 22, 611-617, 1985.

7. Godal, T., Davies, C., Smeland, E.B., Heikkilä, R., Funderud, S., Steen, H.B., and Hildrum, K. Antibodies to surface IgM and IgD increase the expression of various class II antigens on human B cells. Eur. J. Immunol., 15, 173-177, 1985.

8. Lea, T., Vartdal, F., Davies, C., and Ugelstad, J. Magnetic monosized polymer particles for fast and specific fractionation of human mononuclear cells. Scand. J. Immunol., 22, 207-216, 1985.

9. Davies, C .de L., Western, A., Lindmo, T., and Moan, J. Changes in the antigen expression on human FME melanoma cells after exposure to photoactivated hematoporphyrin derivative. Cancer Res., 46, 6068-6072, 1986.

10. Lea, T., Smeland E., Funderud, S., Vartland, F., Davies, C., Beiske, K., and Ugelstad., J. Characterization of human mononuclear cells after positive selection with immunomagnetic particles. Scand. J. Immunol., 23, 509-515, 1986.

11. Roftad, E.K., Wahl, A., Davies, C. de L., and Brustad, T. Growth characteristics of human melanoma multicellular spheroids in liquid-overlay cultures: Comparisons with the parent tumour xenografts. Cell Tissue Kinet., 19, 205-216, 1986.

12. Beiske, K., Munthe-Kaas, A., Davies, C. de L., Marton, P.F., and Godal, T. Single cell studies on the immunological marker profile of plasmacytoid T-zone cells. Lab. Invest., 56, 381-393, 1987.

13. Holte, H., Davies, C. de L., Kvaløy, S., Smeland, E.B., Foss-Abrahamsen A., Kaalhus, O., Marton, P.F., and Godal, T. The activation-associated antigen 4F2 predicts patient survival in low-grade B-cell lymphomas. Int. J. Cancer, 39, 590-594, 1987.

14. Lømo, J., Holte, H., Davies, C. de L., Ruud, E., Laukas, M., Smeland E., Godal T., and Blomhoff, H.K. Downregulation of c-myc RNA is not a prerequisite for reduced cell proliferation, but is associated with G1 arrest in B-lymphoid cell lines. Exp. Cell Res., 172, 84-91, 1987.

15. Davies, C. de L., Ranheim, T., Malik, Z., Rofstad, E.K., Moan J., and Lindmo, T. Relationship between changes in antigen expression and protein synthesis in human melanoma cells after hyperthermia and photodynamic treatment. Br. J. Cancer, 58, 306-313, 1988.

16. Blomhoff, H.K., Blomhoff, R., Stokke, T., Davies, C. de L., Brevik, K., Smeland, E.B., Funderud, S., and Godal, T. cAMP-mediated growth inhibition of a B-lymhoid precursor cell-line Reh is associated with an early transient delay in G2/M, followed by an accumulation of cells in G1. J. Cell. Physiol., 137, 583-587, 1988.

17. Smeland, E.B., Blomhoff, H.K., Ohlsson, R., Davies, C de L., Funderud, S., and Boye, E. Transcription of protooncogenes during stimulation of normal human B lymphocytes. Eur. J. Immunol., 18, 1847-1850, 1988.

18. Davies, C. de L., Pettersen, E.O., and Lindmo, T. Changes in antigen expression on human FME melanoma cells after exposure to hypoxia and acidic pH, alone or in combination. Int. J. Cancer, 43, 350-355, 1989.

19. Erikstein, B.K., Beiske, K., Smeland, E.B., Davies, C. de L., Blomhoff, H.K., and Funderud, S. Characterization of MAB B41 (HH2) recognizing a cell cycle regulated formol-resistant antigen specific for human B-cells. In: Leucocyte Typing IV . W. Knapp et.al.(eds), Oxford University Press, Oxford, pp.110-112, 1989.

20. Davies, C. de L., Basham, T.Y., Anderson, R.L., and Hahn, G.M. Changes in the expression of idiotype antigen on murine B-cell lymphoma after hyperthermia alone and in combination with interferon and tumour necrosis factor. Int. J. Cancer, 45, 500-507, 1990.

21. Davies, C. de L., and Kovacs, M. Measurement of DNA and antigen expression of live cells using three fluorochromes and two detectors. Cytometry, 11, 533-538, 1990.

22. Davies, C. de L., and Lindmo, T. Hyperthermia-induced shedding and masking of melanoma-associated antigen. Int. J. Hyperthermia, 6, 1053-1064, 1990.

23. Holte, H., Davies, C. de L., Beiske, K., Stokke, T., Marton, P.F., Smeland, E.B., Høie, J., and Kvaløy, S. Ki67 and 4F2 antigen expression as well as DNA synthesis predict survival at relapse/tumour progression in low-grade B-cell lymphoma. Int. J. Cancer, 44, 975-980, 1989.

24. Stokke, T., Holte, H., Davies, C. de L., Steen, H.B., and Lie, S.O. Quenching of Hoechst 33258 fluorescence in erythroid precursors. Cytometry, 11, 686-690, 1990.

25. Myklebust, A.T., Beiske, K., Pharo, A., Davies, C.de L., Aamdal S., and Fodstad, Ø. Selection of anti-SCLC antibodies for diagnosis of bone marrow metastases. Br. J. Cancer, 63, suppl. XIV, 49-53, 1991.

26. Myrseth, L.E., Gulowsen, A.C., Davies, C. de L., Grandaunet, J., Brosstad,F., and Prytz, H. Is the RPM cell line a useful model for the study of megakarocyte development? Exp. Hematology, 18, 1073-1077, 1990.

27. Stokke, T., Holte, H., Erikstein, B., Davies, C. de L., Funderud, S., and Steen, H. Simultaneous assessment of chromatin structure, DNA content, and antigen expression by dual wavelength excitation flow cytometry. Cytometry, 12, 172-178, 1991.

28. Erikstein, B.K., Funderud, S., Beiske, K., Aas-Eng, A., Davies, C. de L., Blomhoff, H.K., and Smeland, E.B. Cell cycle-dependent regulation of CDw75 b-galactoside a-2,6-sialyltransferase) on human B lymphocytes. Eur. J. Immunol., 22, 1149-1155, 1992.

29. Hjelstuen M.H., and Davies, C. de L. Flow cytometric measurements of heat shock proteins. Int. J. Hyperthermia, 10, 283-295, 1994.

30. Davies, C. de L., and Falch, B.M.H. Expression of melanoma-associated antigen of thermo- tolerant human cells. Int. J. Hyperthermia, 12, 539-549, 1996.

31. Hjelstuen M. H., Rasch-Halvorsen, K., Brekken, C., Bruland, Ø., and Davies, C. de L. Penetration and binding of monoclonal antibody in human osteosarcoma multicell spheroids. Comparison of confocal laser scanning microscopy and autoradiography. Acta Oncologica, 35, 273-279, 1996.

32. Davies, C. de L., Müller, H., Hagen, I., Gårseth, M., and Hjelstuen M.H. Comparison of extracellular matrix in human osteosarcomas and melanomas growing as xenografts, multicellular spheroids, and monolayer cultures. Anticancer Res., 17, 4317-4326, 1997.

33. Hjelstuen, M. H., Rasch-Halvorsen, K., Bruland, Ø., and Davies, C. de L. Uptake, penetration, and binding of monoclonal antibodies with increasing affinity in human osteosarcoma multicell spheroids. Anticancer Res. 18, 3153-3162, 1998.

34. Brekken, C., and Davies, C. de L. Hyaluronidase reduces the interstitial fluid pressure in solid tumours in a non-linear concentration-dependent manner. Cancer Letter, 131, 65-70, 1998.

35. Brekken, C., Bruland Ø. S. and Davies, C. de L. Interstitial fluid pressure in human osteosarcoma xenografts: Significance of implantation site and the response to intratumoral injection of hyaluronidase. Anticancer Res. 20, 3503-3512, 2000

36. Brekken, C., Hjelstuen, M H., Bruland Ø. S. and Davies, C. de L. Hyaluronidase-induced periodic modulation of the interstitial fluid pressure increases selective antibody uptake in human osteosarcoma xenografts. Anticancer Res. 20, 3513-3520, 2000

37. Davies, C. de L., Melder, R.J., Munn, L.L., Jain, R.K., and Boucher, Y. Decorin inhibits endothelial migration and tube-like structure formation: Role of thrombospondin. Microvasc. Res. 62, 26-42, 2001

38. Davies, C. de L., Engeseter, B., Haug, I., Ormeberg I W., Halgunset J., and Brekken C. Uptake of IgG in osteosarcoma correlates inversely with interstitial fluid pressure, but not with interstitial constituents. Br. J. Cancer , 85, 1968-1977, 2001.

39. Davies, C. de L., Berk D.A., Pluen A., Jain R.K. Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells. Br. J. Cancer 86, 1639-1644, 2002.

40. Davies, C. de L., Lundstrøm, L.M., Frengen, J., Eikenes, L., Bruland, Ø., Kaalhus, Hjelstuen, M.H.B., and Brekken., C. Radiation improves the distribution and uptake of liposomal doxorubicin (Caelyx) in humna osteosarcoma xenografts. Cancer Res., 64, 547-553, 2004.

41. Eikenes, L., Bruland, Ø.S., Brekken., C., and Davies, C. de L. Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts. Cancer Res. 64, 4768-47673, 2004.

42. Danielsen, S., Strand, S., Davies, C. de L, and, Stokke BT. Glycosaminoglycan destabilization of DNA-chitosan polyplexes for gene delivery depends on chitosan chain length and GAG properties. Biochim Biophys Acta. 1721(1-3), 44-54, 2005.

42. Eikenes, L., Tari, M., Tufto, I., Bruland Ø., and Davies, C. deL. Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx^TM) in human osteosarcoma xenografts. Br. J. Cancer , 93, 81-88, 2005

43. Erikson, A. Ortegren, J. Hompland T, Davies, C de L, Lindgren M. Quantification of the second-order nonlinear susceptibility of collagen I using a laser scanning microscopy. J Biomedical Optics, 12 (4), 044002, 2007

44. Tufto I, Hansen R, Byberg D, Nygaard KHH, Tuft J, Davies C deL. (2007) The effect of collagenase or hyaluronidase on transient perfusion in human osteosarcoma xenografts grown orthotopically and in dorsal skinfold chamber

AntiCancer Res, 27, 1475-1482, 2007

45. Schnell EA, Eikenes L, Tufto I, Erikson A, Juthajan A, Lindgren M, Davies C deL. Diffusion measured by fluorescence recovery after photobleaching base don multiphoton laser scanning microscopy, Submitted Biophys J, 2007

46. Lilledahl M, Haugen O, Davies C deL, Svaasand LO Characterization of vulnerable plaques by multiphoton microscopy. J Biomedical Optics. 12 (4) 044005, 2007.

47. Erikson A, Andersen HN, Naess SN, Sikorski P, Davies C deL. Physical and chemical modifications of collagen gels: Impact on diffusion. Biopolymers. Accepted, 2007.

Virtuel journals

Lilledahl M, Haugen O, Davies C deL, Svaasand LO Characterization of vulnerable plaques by multiphoton microscopy Virtual Journal of Biological Physics Research, 1.sept 2007.

Abstracts and proceeding:

1. Davies C., Lindmo T., Rofstad E.K., Fodstad Ø., and Sundan A. Antigen expression in human melanoma cells (FME) under different growth conditions. 10^th Int. meeting of the Society for Analytical Cytology, Pacific Grove, California 3-8 June, Abstract D-7, 1984.

2. Davies C., Rofstad E.K.,and Lindmo T. Antigen expression on human melanoma cells (FME) after hyperthermia. Proc. 4^th Int. Symposium on Hyperthermic Oncology, Aarhus 2-6 July 1984. J. Overgaard (ed), Taylor&Frabcis, pp 417-474, 1984.

3. Davies, C. de L., Rofstad E.K., and Lindmo T. Antigen expression and protein synthesis of human melanoma cells (FME) after hyperthermia. 34th Meeting of Radiation 3Research Society, Las Vegas 12-17 April, Abstract 13, 1986.

4. Davies, C. de L., Ranheim T., and Lindmo T. Internalization of melanoma-associated antigns during heating. Meeting of European Society for Hyperthermic Oncology, Cardiff 13-17 July, 1987.

5. Holte H., Davies C., Stokke T., Kvaløy S., Smeland E.B.Expression of activation antigens and oncogens as prognostic markers in B cell neoplasias. 12th Int. Meeting of the Society for Analytical Cytology, Cambridge 9-15 August, 1987.

6. Davies C., Anderson R., Basham T., and Hahn G. Expression of idiotype antigen on murine B-cell lymphoma after hyperthermia alone and combined with interferon and tumor necrosis factor. 5th Int. Symposium on Hyperthermic Oncology, Kyoto 29 Aug-3 Sept, 1988.

7. Davies C, de L. and Kovacs, M. Detection of three fluorochromes using two photomultiplier tubes to measure DNA and surface antigen of live and dead cells after hyperthermia. 14th Int. Meeting of the Society for Analytical Cytology, Asheville, North Carolina, March 18-23, Cytometry suppl 4, Abstract 399A, 1990.

8. Stokke T., Holte H., Davies, C. de L., and Steen H. Simultaneous assessment of chromatin structure, DNA content and antigen expression by dual wavelength flow cytometry. 14th Int. Meeting of the Society for Analytical Cytology. Asheville, North Carolina, March 18-23, Cytometry suppl. 4, Abstract 196, 1990.

9. Hjelstuen M.H., and Davies, C. de L. Measurements of heat shock proteins by flow cytometry. 16th Int. Meeting of the International Society for Analytical Cytology. Colorado Springs, Colorado, March 21-26, Cytometry suppl. 6, Abstract 219B, 1993.

10. Hjelstuen, M.H., Brekken, C., Bruland, Ø., and Davies, C. de L. Penetration and binding of monoclonal antibodies in multicellular spheroids. 17th Int. Meeting of the International Society for Analytical Cytology. Lake Placid, New York, 16-21 October, Cytometry suppl. 7, Abstract 526B, 1994

11. Hjelstuen, M.H., and Davies, C.de L. Penetration of monoclonal antibodies in spheroids studied by confocal microscopy and autoradiography. 4th Scandinavian Symposium on Radiolabeled Monoclonal Antibodies in Diagnosis and Therapy of Cancer. Lillehammer, Norway, 15-17 January, p. 16, 1995.

12. Davies, C. de L, Müller, H., Gårseth, M., Hagen, I., and Hjelstuen M.H. Extracellular matrix measured by fluorescent microscopy. 18th Int. Meeting of the International Society for Analytical Cytology. Rimini, Italy, 12-19 April, Cytometry suppl. 8, Abstract TB82, 1996.

13 Brekken, C., Hjelstuen, H.M. Muller, H., and Davies, C. de L. Measurements of interstitial fluid pressure in solid tumors after single bolus hyaluronidase injection. 45^th Annul meeting of radiation research Society and 16^th annual meeting of north American hyperthermia Society, Providence, Rhode island, USA, May Abstract no P 10-198, 1997.

14. Brekken, C., Hjelstuen M.H., Muren, L., Olsen, G., Bruland Ø., and Davies, C. de L. Uptake of monoclonal antibodies in multicellular spheroids after hyperthermia or hyaluronidase treatment. 45^th Annul meeting of radiation research Society and 16^th annual meeting of north American hyperthermia Society, Providence, Rhode island, USA, May Abstract no MP03-9, 1997.

15. Davies, C. de L, Müller, H., Gårseth, M., Hagen, I., and Hjelstuen M.H. A comparison of extracellular matrix in tumors, multicell spheroids, and cell culture. 45^th Annul meeting of radiation research Society and 16^th annual meeting of north American hyperthermia Society, Providence, Rhode island, USA, May Abstract no P26- 522, 1997.

16 Davies, C .de L., Jain, R.K., and Boucher, Y. The effect of thrombospondin and decorin on tube formation by endothelial. 89 th Annual Meeting Amer. Association for Cancer Res., New Orleans, Abstract. 39, 1998

18. Brekken, C., Haug, I., and Davies, C. de L. Extracellular matrix content and interstitial fluid pressure in relation to macromolecular uptake in solid tumors. 11^th International Congress of Radiation Research, Dublin, Ireland, July 1999.

19. Davies, C. de L., Berk, D., Pluen, A., Jain, R.K. Diffusion and extracellular matrix in Rhabdomyosarcomas growing as tumors in dorsal chambers and multicellular spheroids. 91^th Annual Meeting American Association for Cancer Res. San Francisco, Abstract 405, 2000

20. Hjelstuen M.H., Haraldseth O., Davies C., Gribbestad I.S., Bjørnerud A., Brekken C., Dynamic MRI of osteosarcoma xenografts: The effects of intratumoral hyaluronidase injection on the tumour water diffusion and blood volume. Proc.Intl.Soc.Magn.Reson.Med.8, Vol.2:p.1049, 2000

20. Boucher, Y, Davies C.de L, Griffon-Etienne, G., Gohongi, T., Munn, L.L., Melder, R.J., Jain, R.K. Decorin inhibits endothelial tube-like structure formation and tumor-induced angiogenesis. Annual Meeting American Association for Cancer Res. New Orleans, Abstract 3116, 2001

21. Davies, C. de L., Lundsrøm, L.M. Frengen J., Eikenes, L., Bruland, Ø.S., and Brekken C. Radiation improves the distribution of liposomal doxorubicin in human osteosarcoma xenografts. 93rd Annual Meeting American Association for Cancer Res. San Francisco, Abstract 2400, 2002.

22. Eikenes L, and Davies, C de L. Collagenase increases the transcapillary pressure gradient in human osteosarcoma xenografts. 93rd Annual Meeting American Association for Cancer Res. San Francisco, Abstract 2923, 2002.

23. Davies C de L., ØS Bruland, and MR Tari. Hyaluronidase improves the distribuion of liposomal doxorubicin in human osteosarcoma xenografts. Int J Cancer, suppl. 13, p 425-526. 18^th UICC International Cancer Congress, Oslo, 2002.

24. Eikenes L. Davies, C. de L. Collagenase increases the transcapillary pressure gradient and the antibody uptake in human osteosarcoma xenografts. Int J Cancer, suppl. 13, p 151-152. 18^th UICC International Cancer Congress, Oslo, 2002.

25. Brekken C., Veliyulin, E., Singstad T.E., Frengen J., Eikenes L., Davies C. de L., Bruland Ø.S., Gribbestad I.S. Chemoirradiation of human osteosarcoma in mice: Early response assessment by magnetic resonance imaging. Int J Cancer, suppl. 13, p 95. 18^th UICC International Cancer Congress, Oslo, 2002.

26. Brekken C., Veliyulin, E., Singstad T.E., Frengen J., Eikenes L., Davies C. de L., Bruland Ø.S., Gribbestad I.S. Chemoirradiation of human osteosarcoma in mice: Early response assessment by MRI. Proc.Intl.Soc.Magn.Reson.2002

27. Davies C. de L., Eikenes L., Lundstrøm, L.M., Tari, M.R., Brekken, C., Frengen, J., Kaalhus, O., Bruland Ø.S. Distribution of Therapeutic Macromolecules in Osteosarcoma Xenografts In Targeted Cancer Therapies, Tromsø Symposium June 2003, ØS Bruland and T. Flægstad (eds), Ravnetrykk, p 183-188, 2003

28. Davies C. de L., Rønning L.M., and Eikenes L. Hyaluronidase and collagenase affect the interstitial diffusion of macromolecules. 95th Annual Meeting American Association for Cancer Res. Orlando, Florida, Abstract 1210, 2004.

29. Tufto I, Eikenes L., Byberg D, Hansen R, Nygaard Kirsten HH, Davies C de L. Enzymatic degradation of extracellular matrix increases the tumor uptake of therapeutic macromolecules: Comparison of the effect of collagenase and hyaluronidase on perfusion. AACR Special conference: Anti-angiogenesis and drug delivery to tumors. Abstract B1, Boston, Massachusetts, 2005.

30. Erikson A, Ortegren, J, Davies C de L C, Lindgren, M. Second-order nonlinear susceptibilities in collagen I. Northern Optics, Bergen, Norway, June 2006.

31. Lilledahl M, Haugen O, Schnell EA, Erikson A, Davies C de L., Svaasand O. Multiphoton microscopy of vulnerable plaque. Northern Optics, Bergen, Norway, June 2006.

32. Reitan NK, Juthajan A, Lindmo T, Davies C deL. Fluorescence correlation spectroscopy as a method for studying interstitial diffusion in cancer tissue. FCS workshop, Stockholm Dec. 2006.

33. Davies C de L, Erikson A, Tufto I, Lindgren M, Eikenes L. Multiphoton microscopy of the structural collagen network and interstitial diffusion of therapeutic macromolecules in osteosarcoma xenografts: The effect of collagenase and hyaluronidase. 100^th Annual Meeting American Association for Cancer Res. Los Angeles, Abstract 5511, 2007.