Robust Control with Youla Parametrization of Yeast Fed-Batch Cultures

Authors:	Vande Wouwer Alain, Faculte Polytechnique de Mons, Belgium Renard Frederic, Faculte Polytechnique de Mons, Belgium Valentinotti Sergio, Firmenich SA, Switzerland Dumur Didier, Supelec, France
Topic:	8.4 Control of Biotechnological Processes
Session:	Control issues in Biotechnological Systems
Keywords:	Robust control; Adaptive control; Fed-batch fermentation; Biotechnology;

Abstract

Optimal productivity of cultures of S. cerevisiae can be achieved through the regulation of the ethanol concentration at a low value. In this study, a robust control strategy is developed, which requires very little knowledge about the process, i.e. only one yield coefficient and the on-line maesurement of the ethanol concentration. A Youla parametrization is selected in order to reject asymptotically the exponential growth disturbance and to robustify the control scheme against unstructured uncertainties and measurement noise. The performance of the control scheme is illustrated with real on-line experimental data.